Meta-analysis of GWAS on PCSK9 concentrations

We performed GWAS for PCSK9 concentrations in two large cohorts (GCKD (n=4,963) and KORA F3 (n=2,895)). These were meta-analyzed with previously published data by Pott et al. (PMID: 34590679) encompassing together 20,579 individuals of White ancestry (7,780,391 SNPs). The main model was adjusted for age, sex, current smoking, statin treatment and principal components. We further conducted a second meta-analysis in statin-naïve individuals (n=15,390) (7,789,706 SNPs).

Short description of the columns included in the files:

• Chromosome: chromosome number
• Position: chromosomal position of the SNP
• MarkerName: chromosome:position
• Allele1: effect allele
• Allele2: non effect allele
• Freq1: frequency of allele 1
• FreqSE: frequency standard error
• Effect: genetic effect of allele 1
• StdErr: standard error of effect
• p.value: p-value
• Direction: direction of the genetic effect of allele 1 in GCKD, KORA F3 , and Pott et al.data, in this order. (+, increasing-effect; -, decreasing-effect and ?, not included in the study)
• HetISq: I square statistic
• HetChiSq: Q statistic
• HetDf: Qstat DF
• HetPVal: p-value for heterogeneity
• TotalN: number of samples

Downloads

PCSK9 _meta-GWAS_ALL
Samples:	20,579
Variants:	7,780,391
Phenotype:	PCSK9 concentrations
Covariates:	age, sex, current smoking, statin treatment and principal components
Downloads:	All_filtered_MAF_2023-11-08.txt.gz

PCSK9_meta-GWAS_Nonstatins
Samples:	15,390
Variants:	7,789,706
Phenotype:	PCSK9 concentrations
Covariates:	age, sex, current smoking and principal components
Downloads:	Nonstatin_filtered_MAF_2023-11-08.txt.gz

Citations

If you use this data, please cite:

Kheirkhah A, Schachtl-Riess JF, Lamina C, Di Maio S, Koller A, Schönherr S, Coassin S, Forer L, Sekula P, Gieger C, Peters A, Köttgen A, Eckardt KU, Kronenberg F: Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations. Atherosclerosis 386:117384, 2023. PMID: 37989062   Journal Article

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