Meta-analysis of GWAS on PCSK9 concentrations

We performed GWAS for PCSK9 concentrations in two large cohorts (GCKD (n=4,963) and KORA F3 (n=2,895)). These were meta-analyzed with previously published data by Pott et al. (PMID: 34590679) encompassing together 20,579 individuals of White ancestry (7,780,391 SNPs). The main model was adjusted for age, sex, current smoking, statin treatment and principal components. We further conducted a second meta-analysis in statin-naïve individuals (n=15,390) (7,789,706 SNPs).

Short description of the columns included in the files:

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PCSK9 _meta-GWAS_ALL
Samples: 20,579
Variants: 7,780,391
Phenotype: PCSK9 concentrations
Covariates: age, sex, current smoking, statin treatment and principal components
Downloads: All_filtered_MAF_2023-11-08.txt.gz
PCSK9_meta-GWAS_Nonstatins
Samples: 15,390
Variants: 7,789,706
Phenotype: PCSK9 concentrations
Covariates: age, sex, current smoking and principal components
Downloads: Nonstatin_filtered_MAF_2023-11-08.txt.gz

Citations

If you use this data, please cite:

Kheirkhah A, Schachtl-Riess JF, Lamina C, Di Maio S, Koller A, Schönherr S, Coassin S, Forer L, Sekula P, Gieger C, Peters A, Köttgen A, Eckardt KU, Kronenberg F: Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations. Atherosclerosis 386:117384, 2023. PMID: 37989062   Journal Article

Contact

Azin Kheirkhah, PhD
Scientist

+43 512 9003 70575
azin.kheirkhah@i-med.ac.at
Florian Kronenberg, MD, MAE
Full Professor

+43 512 9003 70560
florian.kronenberg@i-med.ac.at