Meta-analysis of GWAS on afamin

Genome-wide association analyses of afamin levels were conducted across eight cohorts (CoLaus, Young Finns Study, KORA F3, KORA F4, and GCKD), in which afamin concentrations were measured using ELISA. These results were meta-analyzed and subsequently combined with publicly available UK Biobank proteomics GWAS summary statistics (Europeans only) generated using Olink technology (PMID: 37794186; https://www.synapse.org/Synapse:syn52361876). The summary statistics provided here correspond to the final combined meta-analysis (total N = 50,599 participants). All analyses were adjusted for age, sex, and four principal components. ELISA-based afamin concentrations were inverse normal–transformed to facilitate harmonization across cohorts.

Short description of the columns included in the file:

• Chromosome: chromosome number
• Position: chromosomal position of the SNP
• MarkerName: chromosome:position
• Allele1: effect allele
• Allele2: non-effect allele
• Freq1: frequency of allele 1
• FreqSE: frequency standard error
• Effect: genetic effect of allele 1
• StdErr: standard error of effect
• p.value: p-value
• Direction: direction of the genetic effect of allele 1 in ELISA-based studies and the UKB data, in this order. (+, increasing-effect; -, decreasing-effect and ?, not included in the study)
• HetISq: I square statistic
• HetChiSq: Q statistic
• HetDf: Qstat DF
• HetPVal: p-value for heterogeneity
• Total N or N: number of samples

These summary statistics include only variants for which data from the ELISA-based studies are available and results were filtered using a MAF > 0.001.

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Contact

Barbara Kollerits, PhD, MPH
Associate Professor

+43 512 9003 70566
barbara.kollerits@i-med.ac.at

Adriana Koller, PhD.
Postdoc

+43 512 9003 70582
adriana.koller@i-med.ac.at

Florian Kronenberg, MD, MAE
Full Professor

+43 512 9003 70560
florian.kronenberg@i-med.ac.at