Research
Lead:
Florian Kronenberg
Co-Lead:
Claudia Lamina
Barbara Kollerits
Although Lp(a) is well established as a causal risk factor for cardiovascular disease, many questions still deserve further research. We are interested in the genetic and non-genetic factors which are influencing Lp(a) concentrations.
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Highlighted Publications
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Di Maio S, Lamina C, Coassin S, Forer L, Würzner R, Schönherr S, Kronenberg F:
Lipoprotein(a) and SARS-CoV-2 infections: Susceptibility to infections, ischemic heart disease and thromboembolic events.
J. Intern. Med.
291:101-107, 2022. PMID:
34096654
Journal Article
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Lamina C, Kronenberg F, Lp(a)-GWAS-Consortium:
Estimation of the required lipoprotein(a)-lowering therapeutic effect size for reduction in coronary heart disease outcomes: A Mendelian randomization analysis.
JAMA Cardiol.
4:575-579, 2019. PMID:
31017618
Journal Article
Lead:
Stefan Coassin
Co-Lead:
Florian Kronenberg
Sebastian Schönherr
We are interested in understanding how functional genetic variants in LPA contribute to the huge variance in lipoprotein(a) concentrations observed between individuals and across ancestries and identifying the causal mechanisms.
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Highlighted Publications
Lead:
Sebastian Schönherr
Lukas Forer
Hansi Weissensteiner
We develop novel algorithms and computational tools to explore the genetics of various phenotypes.
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Highlighted Projects
Highlighted Publications
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Das S*, Forer L*, Schönherr S*, Sidore C, Locke AE, Kwong A, Vrieze SI, Chew EY, Levy S, McGue M, Schlessinger D, Stambolian D, Loh PR, Iacono WG, Swaroop A, Scott LJ, Cucca F, Kronenberg F, Boehnke M, Abecasis GR, Fuchsberger C:
Next-generation genotype imputation service and methods.
Nat. Genet.
48:1284-1287, 2016. PMID:
27571263
Journal Article
Lead:
Lukas Forer
Sebastian Schönherr
Askimed is a eCRF software and cloud platform developed and maintained by our lab.
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Lead:
Florian Kronenberg
Co-Lead:
Claudia Lamina
Barbara Kollerits
Hans Dieplinger
We investigate several biomarkers in the context of complex diseases such as atherosclerosis or chronic kidney disease.
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Highlighted Projects
Highlighted Publications
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Schwaiger JP, Kollerits B, Steinbrenner I, Weissensteiner H, Schönherr S, Forer L, Kotsis F, Lamina C, Schneider MP, Schultheiss UT, Wanner C, Köttgen A, Eckardt KU, Kronenberg F, GCKD Investigators:
Apolipoprotein A-IV concentrations and clinical outcomes in a large chronic kidney disease cohort: Results from the GCKD study.
J. Intern. Med.
291:622-636, 2022. PMID:
34914850
Journal Article
Lead:
Claudia Lamina
Evaluation and implementation of statistical methods in genetics
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Lead:
Bernhard Rupp
Sebastiaan Werten
The Structural Biology Group conducts independent FWF funded research and provides collaborative support in structural determination and computational modelling throughout the campus.
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Lead:
Florian Kronenberg
Epidemiological and genetic expertise on e.g. lipoproteins as well as chronic kidney disease resulted in several contributions in working groups of guidelines and consensus papers.
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Highlighted Publications
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Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky M, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgözoğlu LS, Catapano AL:
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.
Eur. Heart J.
43:3925-3946, 2022. PMID:
36036785
Journal Article