Research
Lead:
Florian Kronenberg
Co-Lead:
Claudia Lamina
Barbara Kollerits
Although Lp(a) is well established as a causal risk factor for cardiovascular disease, many questions still deserve further research. We are interested in the genetic and non-genetic factors which are influencing Lp(a) concentrations.
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Highlighted Publications
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Di Maio S, Lamina C, Coassin S, Forer L, Würzner R, Schönherr S, Kronenberg F:
Lipoprotein(a) and SARS-CoV-2 infections: Susceptibility to infections, ischemic heart disease and thromboembolic events.
J. Intern. Med.
291:101-107, 2022. PMID:
34096654
Journal Article
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Lamina C, Kronenberg F, Lp(a)-GWAS-Consortium:
Estimation of the required lipoprotein(a)-lowering therapeutic effect size for reduction in coronary heart disease outcomes: A Mendelian randomization analysis.
JAMA Cardiol.
4:575-579, 2019. PMID:
31017618
Journal Article
Lead:
Stefan Coassin
Co-Lead:
Florian Kronenberg
Sebastian Schönherr
We are interested in understanding how genetic variants in LPA contribute to the huge variance in lipoprotein(a) concentrations observed between individuals and across ancestries.
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Highlighted Publications
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Coassin S, Kronenberg F:
Lipoprotein(a) beyond the kringle IV repeat polymorphism: The complexity of genetic variation in the LPA gene.
Atherosclerosis
349:17-35, 2022. PMID:
35606073
Review
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Amstler S, Streiter G, Pfurtscheller C, Forer L, Di Maio S, Weissensteiner H, Paulweber B, Schönherr S, Kronenberg F, Coassin S:
Nanopore sequencing with unique molecular identifiers enables accurate mutation analysis and haplotyping in the complex lipoprotein(a) KIV-2 VNTR.
Genome Med.
16:117, 2024. PMID:
39380090
Journal Article
Lead:
Sebastian Schönherr
The Computational and Digital Genomics Lab develops computational tools to identify genetic and non-genetic risk factors associated with chronic diseases, using large biobank-scale datasets.
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Highlighted Projects
Highlighted Publications
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Di Maio S, Zöscher P, Weissensteiner H, Forer L, Schachtl-Riess JF, Amstler S, Streiter G, Pfurtscheller C, Paulweber B, Kronenberg F, Coassin S, Schönherr S:
Resolving intra-repeat variation in medically relevant VNTRs from short-read sequencing data using the cardiovascular risk gene LPA as a model.
Genome Biol.
25:167, 2024. PMID:
38926899
Journal Article
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Weissensteiner H*, Forer L*, Kronenberg F, Schönherr S:
mtDNA-Server 2: advancing mitochondrial DNA analysis through highly parallelized data processing and interactive analytics.
Nucleic Acids Res.
52:W102-W107, 2024. PMID:
38709886
Journal Article
Lead:
Lukas Forer
Co-Lead:
Florian Kronenberg
We develop and use innovative informatics approaches like machine learning technologies to advance our understanding of genomics.
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Highlighted Projects
Highlighted Publications
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Das S*, Forer L*, Schönherr S*, Sidore C, Locke AE, Kwong A, Vrieze SI, Chew EY, Levy S, McGue M, Schlessinger D, Stambolian D, Loh PR, Iacono WG, Swaroop A, Scott LJ, Cucca F, Kronenberg F, Boehnke M, Abecasis GR, Fuchsberger C:
Next-generation genotype imputation service and methods.
Nat. Genet.
48:1284-1287, 2016. PMID:
27571263
Journal Article
Lead:
Claudia Lamina
Evaluation and implementation of statistical methods in genetics
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Lead:
Sebastian Schönherr
Hansi Weissensteiner
Co-Lead:
Lukas Forer
Florian Kronenberg
We contribute to advance our understanding of mitochondrial genomes and their role in human health and disease. Besides developing and providing tools for mtDNA analysis to the research community, we also investigate mtDNA changes on various levels in different disease/phenotypes.
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Highlighted Publications
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Schönherr S, Weissensteiner H, Kronenberg F, Forer L:
Haplogrep 3 - an interactive haplogroup classification and analysis platform.
Nucleic Acids Res.
51:W263-W268, 2023. PMID:
37070190
Journal Article
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Weissensteiner H, Forer L, Fendt L, Kheirkhah A, Salas A, Kronenberg F, Schoenherr S:
Contamination detection in sequencing studies using the mitochondrial phylogeny.
Genome Res.
31:309-316, 2021. PMID:
33452015
Journal Article
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Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Giese I, Sorn P, Sant'Anna-Silva AC, Iglesias-Gonzalez J, Sahin U, Kronenberg F, Gnaiger E, Klocker H:
OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation.
Nat. Commun.
11:1487, 2020. PMID:
32198407
Journal Article
Lead:
Florian Kronenberg
Co-Lead:
Claudia Lamina
Barbara Kollerits
Hans Dieplinger
We investigate several biomarkers in the context of complex diseases such as atherosclerosis or chronic kidney disease.
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Highlighted Projects
Highlighted Publications
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Schwaiger JP, Kollerits B, Steinbrenner I, Weissensteiner H, Schönherr S, Forer L, Kotsis F, Lamina C, Schneider MP, Schultheiss UT, Wanner C, Köttgen A, Eckardt KU, Kronenberg F, GCKD Investigators:
Apolipoprotein A-IV concentrations and clinical outcomes in a large chronic kidney disease cohort: Results from the GCKD study.
J. Intern. Med.
291:622-636, 2022. PMID:
34914850
Journal Article
Lead:
Lukas Forer
Sebastian Schönherr
Askimed is a eCRF software and cloud platform developed and maintained by our lab.
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Lead:
Florian Kronenberg
Epidemiological and genetic expertise on e.g. lipoproteins as well as chronic kidney disease resulted in several contributions in working groups of guidelines and consensus papers.
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Highlighted Publications
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Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky M, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgözoğlu LS, Catapano AL:
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.
Eur. Heart J.
43:3925-3946, 2022. PMID:
36036785
Journal Article