Meta-analysis of GWAS on apolipoprotein A-IV
Genome-wide association analyses of apolipoprotein A-IV (apoA-IV) were conducted across eight cohorts (CoLaus, Young Finns Study, KORA F3, KORA F4, DiaGene, Rotterdam Study, AugUR, and GCKD), in which apoA-IV concentrations were measured using ELISA. These results were meta-analyzed and subsequently combined with publicly available UK Biobank proteomics GWAS summary statistics (Europeans only) generated using Olink technology (PMID: 37794186; https://www.synapse.org/Synapse:syn52361547). The summary statistics provided here correspond to the final combined meta-analysis (total N = 59,176 participants). All analyses were adjusted for age, sex, and four principal components. ELISA-based apoA-IV concentrations were inverse normal–transformed to facilitate harmonization across cohorts.
Short description of the columns included in the file:
- Chromosome: chromosome number
- Position: chromosomal position of the SNP
- MarkerName: chromosome:position-
- Allele1: effect allele
- Allele2: non-effect allele
- Freq1: frequency of allele 1
- FreqSE: frequency standard error
- Effect: genetic effect of allele 1
- StdErr: standard error of effect
- p.value: p-value
- Direction: direction of the genetic effect of allele 1 in ELISA-based studies and the UKB data, in this order. (+, increasing-effect; -, decreasing-effect and ?, not included in the study)
- HetISq: I square statistic
- HetChiSq: Q statistic
- HetDf: Qstat DF
- HetPVal: p-value for heterogeneity
- TotalN: number of samples
These summary statistics include only variants for which data from the ELISA-based studies are available and results were filtered using a MAF > 0.001.
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| ApoAIV_metaanalysis | |
|---|---|
| Samples: | 59,176 |
| Variants: | 15,850,053 |
| Phenotype: | Apolipoprotein A-IV |
| Covariates: | age, sex, and four principal components |
| Downloads: |
ApoAIV_metaanalysis_2026-02-12.zip |
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