Meta-analysis of GWAS on PCSK9 concentrations

We performed GWAS for PCSK9 concentrations in two large cohorts (GCKD (n=4,963) and KORA F3 (n=2,895)). These were meta-analyzed with previously published data by Pott et al. (PMID: 34590679) encompassing together 20,579 individuals of White ancestry (7,780,391 SNPs). The main model was adjusted for age, sex, current smoking, statin treatment and principal components. We further conducted a second meta-analysis in statin-naïve individuals (n=15,390) (7,789,706 SNPs).

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PCSK9 _meta-GWAS_ALL
Samples: 20,579
Variants: 7,780,391
Phenotype: PCSK9 concentrations
Covariates: age, sex, current smoking, statin treatment and principal components
Downloads: All_filtered_MAF_2023-11-08.txt.gz
PCSK9_meta-GWAS_Nonstatins
Samples: 15,390
Variants: 7,789,706
Phenotype: PCSK9 concentrations
Covariates: age, sex, current smoking and principal components
Downloads: Nonstatin_filtered_MAF_2023-11-08.txt.gz

Contact

Azin Kheirkhah, MSc.
PhD Student

+43 512 9003 70575
azin.kheirkhah@i-med.ac.at
Florian Kronenberg, MD, MAE
Full Professor

+43 512 9003 70560
florian.kronenberg@i-med.ac.at