Research Interests
- Biochemical and functional characterization of afamin, a human plasma protein involved in metabolic syndrome and related metabolic disorders, various cancers and infertility
- Establishment of an Austrian-wide registry for Familial Hypercholesterolemia
Publications
2023 (1)
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Schwaninger G, Forer L, Ebenbichler C, Dieplinger H, Kronenberg F, Zschocke J, Witsch-Baumgartner M:
Filling the gap: Genetic risk assessment in hypercholesterolemia using LDL-C and LPA genetic scores.
Clin. Genet.
104:334-343, 2023. PMID:
37417318
Journal Article
2022 (3)
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Pitkänen N, Finkenstedt A, Lamina C, Juonala M, Kähönen M, Mäkelä KM, Dieplinger B, Viveiros A, Melmer A, Leitner I, Kedenko L, Seppälä I, Viikari JSA, Mueller T, Kronenberg F, Paulweber B, Lehtimäki T, Zoller H, Raitakari OT, Dieplinger H:
Afamin predicts the prevalence and incidence of nonalcoholic fatty liver disease.
Clin. Chem. Lab. Med.
60:243-251, 2022. PMID:
34850615
Journal Article
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Jahn B, Santamaria J, Dieplinger H, Binder CJ, Ebenbichler C, Scholl-Bürgi S, Conrads-Frank A, Rochau U, Kühne F, Stojkov I, Todorovic J, James L, Siebert U:
Familial hypercholesterolemia: A systematic review of modeling studies on screening interventions.
Atherosclerosis
355:15-29, 2022. PMID:
35870306
Review
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März W, Beil FU, Dieplinger H:
Genetic diseases of lipid metabolism - Focus familial hypercholesterolemia.
Dtsch. Med. Wochenschr.
147:e50-e61, 2022. PMID:
35545064
Review
2021 (2)
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Futema M, Ramaswami U, Tichy L, Bogsrud MP, Holven KB, Roeters van Lennep J, Wiegman A, Descamps OS, De Leener A, Fastre E, Vrablik M, Freiberger T, Esterbauer H, Dieplinger H, Greber-Platzer S, Medeiros AM, Bourbon M, Mollaki V, Drogari E, Humphries SE:
Comparison of the mutation spectrum and association with pre and post treatment lipid measures of children with heterozygous familial hypercholesterolaemia (FH) from eight European countries.
Atherosclerosis
319:108-117, 2021. PMID:
33508743
Journal Article
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Kurdiova T, Balaz M, Kovanicova Z, Zemkova E, Kuzma M, Belan V, Payer J, Gasperikova D, Dieplinger H, Ukropcova B, Ukropec J:
Serum afamin a novel marker of increased hepatic lipid content.
Front. Endocrinol. (Lausanne)
12:670425, 2021. PMID:
34603196
Journal Article
2020 (1)
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Ramaswami U, Futema M, Bogsrud MP, Holven KB, Roeters van Lennep J, Wiegman A, Descamps OS, Vrablik M, Freiberger T, Dieplinger H, Greber-Platzer S, Hanauer-Mader G, Bourbon M, Drogari E, Humphries SE:
Comparison of the characteristics at diagnosis and treatment of children with heterozygous familial hypercholesterolaemia (FH) from eight European countries.
Atherosclerosis
292:178-187, 2020. PMID:
31809987
Journal Article
2019 (2)
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Scharnagl H, Stojakovic T, Dieplinger B, Dieplinger H, Erhart G, Kostner GM, Herrmann M, März W, Grammer TB:
Comparison of lipoprotein (a) serum concentrations measured by six commercially available immunoassays.
Atherosclerosis
289:206-213, 2019. PMID:
31493849
Journal Article
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Köninger A, Iannaccone A, Hajder E, Frank M, Schmidt B, Schleussner E, Kimmig R, Gellhaus A, Dieplinger H:
Afamin predicts gestational diabetes in polycystic ovary syndrome patients preconceptionally.
Endocr. Connect.
8:616-624, 2019. PMID:
30991357
Journal Article
2018 (5)
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Köninger A, Enekwe A, Mach P, Andrikos D, Schmidt B, Frank M, Birdir C, Kimmig R, Gellhaus A, Dieplinger H:
Afamin: an early predictor of preeclampsia.
Arch. Gynecol. Obstet.
298:1009-1016, 2018. PMID:
30220025
Journal Article
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Tramontana A, Pablik E, Stangl G, Hartmann B, Dieplinger H, Hafner E:
Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies.
Placenta
62:Sep.15, 2018. PMID:
29405972
Journal Article
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Altamirano A, Naschberger A, Fürnrohr BG, Saldova R, Struwe WB, Jennings PM, Millán Martín S, Malic S, Plangger I, Lechner S, Pisano R, Peretti N, Linke B, Aguiar MM, Fresser F, Ritsch A, Lenac Rovis T, Goode C, Rudd PM, Scheffzek K, Rupp B, Dieplinger H:
Expression, purification, and biochemical characterization of human afamin.
J. Proteome Res.
17:1269-1277, 2018. PMID:
29441788
Journal Article
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Köninger A, Mathan A, Mach P, Frank M, Schmidt B, Schleussner E, Kimmig R, Gellhaus A, Dieplinger H:
Is Afamin a novel biomarker for gestational diabetes mellitus? A pilot study.
Reprod. Biol. Endocrinol.
16:30, 2018. PMID:
29587878
Journal Article
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Tramontana A, Dieplinger B, Stangl G, Hafner E, Dieplinger H:
First trimester serum afamin concentrations are associated with the development of pre-eclampsia and gestational diabetes mellitus in pregnant women.
Clin. Chim. Acta
476:160-166, 2018. PMID:
29191735
Journal Article
2017 (2)
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Kollerits B, Lamina C, Huth C, Marques-Vidal P, Kiechl S, Seppälä I, Cooper J, Hunt SC, Meisinger C, Herder C, Kedenko L, Willeit J, Thorand B, Dähnhardt D, Stöckl D, Willeit K, Roden M, Rathmann W, Paulweber B, Peters A, Kähönen M, Lehtimäki T, Raitakari OT, Humphries SE, Vollenweider P, Dieplinger H, Kronenberg F:
Plasma concentrations of afamin are associated with prevalent and incident type 2 diabetes: A pooled analysis in more than 20,000 individuals.
Diabetes Care
40:1386-1393, 2017. PMID:
28877915
Journal Article
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Naschberger A, Orry A, Lechner S, Bowler MW, Nurizzo D, Novokmet M, Keller MA, Oemer G, Seppi D, Haslbeck M, Pansi K, Dieplinger H, Rupp B:
Structural evidence for a role of the multi-functional human glycoprotein afamin in Wnt transport.
Structure
25:1907-1915.e5, 2017. PMID:
29153507
Journal Article
2016 (5)
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Kollerits B, Drechsler C, Krane V, Lamina C, März W, Dieplinger H, Ritz E, Wanner C, Kronenberg F, German Diabetes and Dialysis Study Investigators:
Lipoprotein(a) concentrations, apolipoprotein(a) isoforms and clinical endpoints in haemodialysis patients with type 2 diabetes mellitus: results from the 4D Study.
Nephrol. Dial. Transplant
31:1901-1908, 2016. PMID:
26754832
Journal Article
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Naschberger A, Fürnrohr BG, Lenac Rovis T, Malic S, Scheffzek K, Dieplinger H, Rupp B:
The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling.
Acta Crystallogr. D Struct. Biol.
72:1267-1280, 2016. PMID:
27917827
Journal Article
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EAS Familial Hypercholesterolaemia Studies Collaboration, Vallejo-Vaz AJ, Akram A, Kondapally Seshasai SR, Cole D, Watts GF, Hovingh GK, Kastelein JJ, Mata P, Raal FJ, Santos RD, Soran H, Freiberger T, Abifadel M, Aguilar-Salinas CA, Alnouri F, Alonso R, Al-Rasadi K, Banach M, Bogsrud MP, Bourbon M, Bruckert E, Car J, Ceska R, Corral P, Descamps O, Dieplinger H, Do CT, Durst R, Ezhov MV, Fras Z, Gaita D, Gaspar IM, Genest J, Harada-Shiba M, Jiang L, Kayikcioglu M, Lam CS, Latkovskis G, Laufs U, Liberopoulos E, Lin J, Lin N, Maher V, Majano N, Marais AD, März W, Mirrakhimov E, Miserez AR, Mitchenko O, Nawawi H, Nilsson L, Nordestgaard BG, Paragh G, Petrulioniene Z, Pojskic B, Reiner Ž, Sahebkar A, Santos LE, Schunkert H, Shehab A, Slimane MN, Stoll M, Su TC, Susekov A, Tilney M, Tomlinson B, Tselepis AD, Vohnout B, Widén E, Yamashita S, Catapano AL, Ray KK:
Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration.
Atheroscler. Suppl.
22:Jan.32, 2016. PMID:
27939304
Journal Article
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Toplak H, Ludvik B, Lechleitner M, Dieplinger H, Föger B, Paulweber B, Weber T, Watschinger B, Horn S, Wascher TC, Drexel H, Brodmann M, Pilger E, Rosenkranz A, Pohanka E, Oberbauer R, Traindl O, Roithinger FX, Metzler B, Haring HP, Kiechl S:
Austrian Lipid Consensus on the management of metabolic lipid disorders to prevent vascular complications: A joint position statement issued by eight medical societies. 2016 update.
Wien. Klin. Wochenschr.
128 Suppl 2:S216-28, 2016. PMID:
27052248
Journal Article
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März W, Scharnagl H, Gouni-Berthold I, Silbernagel G, Dressel A, Grammer TB, Landmesser U, Dieplinger H, Windler E, Laufs U:
LDL-cholesterol: Standards of treatment 2016: A German perspective.
Am. J. Cardiovasc. Drugs
16:323-336, 2016. PMID:
27430233
Review
2015 (2)
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Vallejo-Vaz AJ, Kondapally Seshasai SR, Cole D, Hovingh GK, Kastelein JJ, Mata P, Raal FJ, Santos RD, Soran H, Watts GF, Abifadel M, Aguilar-Salinas CA, Akram A, Alnouri F, Alonso R, Al-Rasadi K, Banach M, Bogsrud MP, Bourbon M, Bruckert E, Car J, Corral P, Descamps O, Dieplinger H, Durst R, Freiberger T, Gaspar IM, Genest J, Harada-Shiba M, Jiang L, Kayikcioglu M, Lam CS, Latkovskis G, Laufs U, Liberopoulos E, Nilsson L, Nordestgaard BG, O'Donoghue JM, Sahebkar A, Schunkert H, Shehab A, Stoll M, Su TC, Susekov A, Widén E, Catapano AL, Ray KK:
Familial hypercholesterolaemia: A global call to arms.
Atherosclerosis
243:257-259, 2015. PMID:
26408930
Journal Article
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Dieplinger H, Dieplinger B:
Afamin--A pleiotropic glycoprotein involved in various disease states.
Clin. Chim. Acta
446:105-110, 2015. PMID:
25892677
Review
2014 (6)
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Kronenberg F, Kollerits B, Kiechl S, Lamina C, Kedenko L, Meisinger C, Willeit J, Huth C, Wietzorrek G, Altmann ME, Thorand B, Melmer A, Dähnhardt D, Santer P, Rathmann W, Paulweber B, Koenig W, Peters A, Adham IM, Dieplinger H:
Plasma concentrations of afamin are associated with the prevalence and development of metabolic syndrome.
Circ. Cardiovasc. Genet.
7:822-829, 2014. PMID:
25176938
Journal Article
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Seeber B, Morandell E, Lunger F, Wildt L, Dieplinger H:
Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome.
Reprod. Biol. Endocrinol.
12:88, 2014. PMID:
25208973
Journal Article
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Hubalek M, Buchner H, Mörtl MG, Schlembach D, Huppertz B, Firulovic B, Köhler W, Hafner E, Dieplinger B, Wildt L, Dieplinger H:
The vitamin E-binding protein afamin increases in maternal serum during pregnancy.
Clin. Chim. Acta
434:41-47, 2014. PMID:
24768783
Journal Article
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Klose G, Beil FU, Dieplinger H, von Eckardstein A, Föger B, Gouni-Berthold I, Heigl F, Koenig W, Kostner GM, Landmesser U, Laufs U, Leistikow F, März W, Noll G, Parhofer KG, Paulweber B, Riesen WF, Schaefer JR, Steinhagen-Thiessen E, Steinmetz A, Toplak H, Wanner C, Windler E, American Heart Association, American College of Cardiology:
New AHA and ACC guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk.
Wien. Klin. Wochenschr.
126:169-175, 2014. PMID:
24615676
Journal Article
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Klose G, Beil FU, Dieplinger H, von Eckardstein A, Föger B, Gouni-Berthold I, Koenig W, Kostner GM, Landmesser U, Laufs U, Leistikow F, März W, Merkel M, Müller-Wieland D, Noll G, Parhofer KG, Paulweber B, Riesen W, Schaefer JR, Steinhagen-Thiessen E, Steinmetz A, Toplak H, Wanner C, Windler E:
New AHA and ACC guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk : Statement of the D•A•CH Society for Prevention of Cardiovascular Diseases, the Austrian Atherosclerosis Society and the Working Group on Lipids and Atherosclerosis (AGLA) of the Swiss Society for Cardiology.
Internist (Berl.)
55:601-606, 2014. PMID:
24770979
Journal Article
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Köninger A, Edimiris P, Koch L, Enekwe A, Lamina C, Kasimir-Bauer S, Kimmig R, Dieplinger H:
Serum concentrations of afamin are elevated in patients with polycystic ovary syndrome.
Endocr. Connect.
3:120-126, 2014. PMID:
24928911
Journal Article
2013 (4)
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Schwaiger JP, Nakada Y, Berberich R, Ikewaki K, Dieplinger B, Zitt E, Neyer U, Salmhofer H, Kronenberg F, Koenig P, Dieplinger H:
Lipoprotein kinetics in male hemodialysis patients treated with atorvastatin.
Clin. J. Am. Soc. Nephrol.
8:1319-1326, 2013. PMID:
23599405
Journal Article
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Melmer A, Fineder L, Lamina C, Kollerits B, Dieplinger B, Braicu I, Sehouli J, Cadron I, Vergote I, Mahner S, Zeimet AG, Castillo-Tong DC, Ebenbichler CF, Zeillinger R, Dieplinger H:
Plasma concentrations of the vitamin E-binding protein afamin are associated with overall and progression-free survival and platinum sensitivity in serous ovarian cancer--a study by the OVCAD consortium.
Gynecol. Oncol.
128:38-43, 2013. PMID:
23063758
Journal Article
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Dieplinger B, Egger M, Gabriel C, Poelz W, Morandell E, Seeber B, Kronenberg F, Haltmayer M, Mueller T, Dieplinger H:
Analytical characterization and clinical evaluation of an enzyme-linked immunosorbent assay for measurement of afamin in human plasma.
Clin. Chim. Acta
425:236-241, 2013. PMID:
23981841
Journal Article
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Kim BJ, Lee YS, Lee SY, Park SY, Dieplinger H, Yea K, Lee SH, Koh JM, Kim GS:
Afamin stimulates osteoclastogenesis and bone resorption via Gi-coupled receptor and Ca2+/calmodulin-dependent protein kinase (CaMK) pathways.
J. Endocrinol. Invest.
36:876-882, 2013. PMID:
23698732
Journal Article
2012 (5)
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Dieplinger B, Dieplinger H:
New Insights into the Assembly and Metabolism of ApoB-Containing Lipoproteins from in vivo Kinetic Studies: Results on Healthy Subjects and Patients with Chronic Kidney Disease. In: Frank S, Kostner G: Lipoproteins - Role in Health and Diseases.
2012:21-44, 2012. PMID:
Book Chapter
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Frischmann ME, Ikewaki K, Trenkwalder E, Lamina C, Dieplinger B, Soufi M, Schweer H, Schaefer JR, König P, Kronenberg F, Dieplinger H:
In vivo stable-isotope kinetic study suggests intracellular assembly of lipoprotein(a).
Atherosclerosis
225:322-327, 2012. PMID:
23099120
Journal Article
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Kim BJ, Lee YS, Lee SY, Park SY, Dieplinger H, Ryu SH, Yea K, Choi S, Lee SH, Koh JM, Kim GS:
Afamin secreted from nonresorbing osteoclasts acts as a chemokine for preosteoblasts via the Akt-signaling pathway.
Bone
51:431-440, 2012. PMID:
22749887
Journal Article
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Finkenstedt A, Widschwendter A, Brasse-Lagnel CG, Theurl I, Hubalek M, Dieplinger H, Tselepis C, Ward DG, Vogel W, Zoller H:
Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy.
Blood Cells Mol. Dis.
48:233-237, 2012. PMID:
22365732
Journal Article
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Petersen AK, Stark K, Musameh MD, Nelson CP, Römisch-Margl W, Kremer W, Raffler J, Krug S, Skurk T, Rist MJ, Daniel H, Hauner H, Adamski J, Tomaszewski M, Döring A, Peters A, Wichmann HE, Kaess BM, Kalbitzer HR, Huber F, Pfahlert V, Samani NJ, Kronenberg F, Dieplinger H, Illig T, Hengstenberg C, Suhre K, Gieger C, Kastenmüller G:
Genetic associations with lipoprotein subfractions provide information on their biological nature.
Hum. Mol. Genet.
21:1433-1443, 2012. PMID:
22156577
Journal Article
2010 (1)
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Seeber BE, Czech T, Buchner H, Barnhart KT, Seger C, Daxenbichler G, Wildt L, Dieplinger H:
The vitamin E-binding protein afamin is altered significantly in the peritoneal fluid of women with endometriosis.
Fertil. Steril.
94:2923-2926, 2010. PMID:
20858448
Journal Article
2009 (4)
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Gnewuch C, Liebisch G, Langmann T, Dieplinger B, Mueller T, Haltmayer M, Dieplinger H, Zahn A, Stremmel W, Rogler G, Schmitz G:
Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease.
World J. Gastroenterol.
15:3134-3141, 2009. PMID:
19575493
Journal Article
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Dieplinger H, Ankerst DP, Burges A, Lenhard M, Lingenhel A, Fineder L, Buchner H, Stieber P:
Afamin and apolipoprotein A-IV: novel protein markers for ovarian cancer.
Cancer Epidemiol. Biomarkers Prev.
18:1127-1133, 2009. PMID:
19336561
Journal Article
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Kratzer I, Bernhart E, Wintersperger A, Hammer A, Waltl S, Malle E, Sperk G, Wietzorrek G, Dieplinger H, Sattler W:
Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier.
J. Neurochem.
108:707-718, 2009. PMID:
19046407
Journal Article
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N'Diaye M, Le Ferrec E, Kronenberg F, Dieplinger H, Le Vee M, Fardel O:
TNFalpha- and NF-kappaB-dependent induction of the chemokine CCL1 in human macrophages exposed to the atherogenic lipoprotein(a).
Life Sci.
84:451-457, 2009. PMID:
19302817
Journal Article
2007 (5)
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Frischmann ME, Kronenberg F, Trenkwalder E, Schaefer JR, Schweer H, Dieplinger B, Koenig P, Ikewaki K, Dieplinger H:
In vivo turnover study demonstrates diminished clearance of lipoprotein(a) in hemodialysis patients.
Kidney Int.
71:1036-1043, 2007. PMID:
17299521
Journal Article
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Dieplinger B, Lingenhel A, Baumgartner N, Poelz W, Dieplinger H, Haltmayer M, Kronenberg F, Mueller T:
Increased serum lipoprotein(a) concentrations and low molecular weight phenotypes of apolipoprotein(a) are associated with symptomatic peripheral arterial disease.
Clin. Chem.
53:1298-1305, 2007. PMID:
17525104
Journal Article
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Orsó E, Moehle C, Boettcher A, Szakszon K, Werner T, Langmann T, Liebisch G, Buechler C, Ritter M, Kronenberg F, Dieplinger H, Bornstein SR, Stremmel W, Schmitz G:
The satiety factor apolipoprotein A-IV modulates intestinal epithelial permeability through its interaction with alpha-catenin: implications for inflammatory bowel diseases.
Horm. Metab. Res.
39:601-611, 2007. PMID:
17712726
Journal Article
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Jackson D, Craven RA, Hutson RC, Graze I, Lueth P, Tonge RP, Hartley JL, Nickson JA, Rayner SJ, Johnston C, Dieplinger B, Hubalek M, Wilkinson N, Perren TJ, Kehoe S, Hall GD, Daxenbichler G, Dieplinger H, Selby PJ, Banks RE:
Proteomic profiling identifies afamin as a potential biomarker for ovarian cancer.
Clin. Cancer Res.
13:7370-7379, 2007. PMID:
18094419
Journal Article
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Kronenberg F, Ikewaki K, Schaefer JR, König P, Dieplinger H:
Kinetic studies of atherogenic lipoproteins in hemodialysis patients: do they tell us more about their pathology?.
Semin. Dial.
20:554-560, 2007. PMID:
17991204
Review
2006 (3)
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Schwaiger JP, Lamina C, Neyer U, König P, Kathrein H, Sturm W, Lhotta K, Gröchenig E, Dieplinger H, Kronenberg F:
Carotid plaques and their predictive value for cardiovascular disease and all-cause mortality in hemodialysis patients considering renal transplantation: a decade follow-up.
Am. J. Kidney Dis.
47:888-897, 2006. PMID:
16632029
Journal Article
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Lingenhel A, Lhotta K, Neyer U, Heid IM, Rantner B, Kronenberg MF, König P, von Eckardstein A, Schober M, Dieplinger H, Kronenberg F:
Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria.
J. Lipid Res.
47:2071-2079, 2006. PMID:
16788210
Journal Article
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Huang HL, Stasyk T, Morandell S, Dieplinger H, Falkensammer G, Griesmacher A, Mogg M, Schreiber M, Feuerstein I, Huck CW, Stecher G, Bonn GK, Huber LA:
Biomarker discovery in breast cancer serum using 2-D differential gel electrophoresis/ MALDI-TOF/TOF and data validation by routine clinical assays.
Electrophoresis
27:1641-1650, 2006. PMID:
16550499
Journal Article
2005 (4)
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Jerkovic L, Voegele AF, Chwatal S, Kronenberg F, Radcliffe CM, Wormald MR, Lobentanz EM, Ezeh B, Eller P, Dejori N, Dieplinger B, Lottspeich F, Sattler W, Uhr M, Mechtler K, Dwek RA, Rudd PM, Baier G, Dieplinger H:
Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression.
J. Proteome Res.
4:889-899, 2005. PMID:
15952736
Journal Article
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Ikewaki K, Schaefer JR, Frischmann ME, Okubo K, Hosoya T, Mochizuki S, Dieplinger B, Trenkwalder E, Schweer H, Kronenberg F, Koenig P, Dieplinger H:
Delayed in vivo catabolism of intermediate-density lipoprotein and low-density lipoprotein in hemodialysis patients as potential cause of premature atherosclerosis.
Arterioscler. Thromb. Vasc. Biol.
25:2615-2622, 2005. PMID:
16195474
Journal Article
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Haiman M, Salvenmoser W, Scheiber K, Lingenhel A, Rudolph C, Schmitz G, Kronenberg F, Dieplinger H:
Immunohistochemical localization of apolipoprotein A-IV in human kidney tissue.
Kidney Int.
68:1130-1136, 2005. PMID:
16105043
Journal Article
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Margesin R, Dieplinger H, Hofmann J, Sarg B, Lindner H:
A cold-active extracellular metalloprotease from Pedobacter cryoconitis--production and properties.
Res. Microbiol.
156:499-505, 2005. PMID:
15862448
Journal Article
2004 (2)
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Kronenberg F, Lingenhel A, Lhotta K, Rantner B, Kronenberg MF, König P, Thiery J, Koch M, von Eckardstein A, Dieplinger H:
The apolipoprotein(a) size polymorphism is associated with nephrotic syndrome.
Kidney Int.
65:606-612, 2004. PMID:
14717931
Journal Article
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Kronenberg F, Lingenhel A, Lhotta K, Rantner B, Kronenberg MF, König P, Thiery J, Koch M, von Eckardstein A, Dieplinger H:
Lipoprotein(a)- and low-density lipoprotein-derived cholesterol in nephrotic syndrome: Impact on lipid-lowering therapy?.
Kidney Int.
66:348-354, 2004. PMID:
15200443
Journal Article
2003 (4)
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Kronenberg F, Lingenhel A, Neyer U, Lhotta K, König P, Auinger M, Wiesholzer M, Andersson H, Dieplinger H:
Prevalence of dyslipidemic risk factors in hemodialysis and CAPD patients.
Kidney Int. Suppl.
63:S113-6, 2003. PMID:
12694323
Journal Article
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Ezeh B, Haiman M, Alber HF, Kunz B, Paulweber B, Lingenhel A, Kraft HG, Weidinger F, Pachinger O, Dieplinger H, Kronenberg F:
Plasma distribution of apoA-IV in patients with coronary artery disease and healthy controls.
J. Lipid Res.
44:1523-1529, 2003. PMID:
12777472
Journal Article
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Kronenberg F, Lhotta K, König P, Margreiter R, Dieplinger H, Utermann G:
Apolipoprotein(a) isoform-specific changes of lipoprotein(a) after kidney transplantation.
Eur. J. Hum. Genet.
11:693-699, 2003. PMID:
12939656
Journal Article
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von Eckardstein A, Crook D, Elbers J, Ragoobir J, Ezeh B, Helmond F, Miller N, Dieplinger H, Bennink HC, Assmann G:
Tibolone lowers high density lipoprotein cholesterol by increasing hepatic lipase activity but does not impair cholesterol efflux.
Clin. Endocrinol. (Oxf.)
58:49-58, 2003. PMID:
12519412
Journal Article
2002 (5)
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Dieplinger H, Kronenberg F:
Renal metabolism of lipoprotein(a). In: Richter V, Rassoul F, Reuter W, Thiery J: Lipoproteinmetabolismus und Atheroskleroseprävention.
2002:29-62, 2002. PMID:
Book Chapter
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Heiser M, Hutter-Paier B, Jerkovic L, Pfragner R, Windisch M, Becker-André M, Dieplinger H:
Vitamin E binding protein afamin protects neuronal cells in vitro.
J. Neural Transm. Suppl.
:337-345, 2002. PMID:
12456077
Journal Article
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Dallinga-Thie G, Bowyer D, Dallinga-Thie G, Dieplinger H, Funke H, Hofker M, Jauhiainen M, Nimpf J, Staels B, Talmud P, Tarugi P:
European lipoprotein club: Report of the 24th ELC annual conference, tutzing, 10-13 September 2001.
Atherosclerosis
162:439-447, 2002. PMID:
11996965
Journal Article
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Horváth L, Császár A, Falus A, Dieplinger H, Horváth A, Puskás E, Halm G, Bányai A, Pálóczi K, László E, Kalabay L, Romics L, Füst G:
IL-6 and lipoprotein(a) [LP(a)] concentrations are related only in patients with high APO(a) isoforms in monoclonal gammopathy.
Cytokine
18:340-343, 2002. PMID:
12160523
Journal Article
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Voegele AF, Jerković L, Wellenzohn B, Eller P, Kronenberg F, Liedl KR, Dieplinger H:
Characterization of the vitamin E-binding properties of human plasma afamin.
Biochemistry
41:14532-14538, 2002. PMID:
12463752
Journal Article
2001 (2)
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Kalina A, Császár A, Füst G, Nagy B, Szalai C, Karádi I, Duba J, Prohászka Z, Horváth L, Dieplinger H:
The association of serum lipoprotein(a) levels, apolipoprotein(a) size and (TTTTA)(n) polymorphism with coronary heart disease.
Clin. Chim. Acta
309:45-51, 2001. PMID:
11408005
Journal Article
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Reblin T, Donarski N, Fineder L, Bräsen JH, Dieplinger H, Thaiss F, Stahl RA, Beisiegel U, Wolf G:
Renal handling of human apolipoprotein(a) and its fragments in the rat.
Am. J. Kidney Dis.
38:619-630, 2001. PMID:
11532696
Journal Article
2000 (2)
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Kronenberg F, Stühlinger M, Trenkwalder E, Geethanjali FS, Pachinger O, von Eckardstein A, Dieplinger H:
Low apolipoprotein A-IV plasma concentrations in men with coronary artery disease.
J. Am. Coll. Cardiol.
36:751-757, 2000. PMID:
10987595
Journal Article
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Böttcher A, Schlosser J, Kronenberg F, Dieplinger H, Knipping G, Lackner KJ, Schmitz G:
Preparative free-solution isotachophoresis for separation of human plasma lipoproteins: apolipoprotein and lipid composition of HDL subfractions.
J. Lipid Res.
41:905-915, 2000. PMID:
10828082
Journal Article
1999 (11)
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Dieplinger H, Utermann G:
The seventh myth of lipoprotein(a): where and how is it assembled?.
Curr. Opin. Lipidol.
10:275-283, 1999. PMID:
10431664
Review
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Dieplinger H, Kronenberg F:
Genetics and metabolism of lipoprotein(a) and their clinical implications (Part 1).
Wien. Klin. Wochenschr.
111:May.20, 1999. PMID:
10067265
Review
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Dieplinger H, Kronenberg F:
Genetics and metabolism of lipoprotein(a) and clinical implications (Part 2).
Wien. Klin. Wochenschr.
111:46-55, 1999. PMID:
10081121
Review
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Kronenberg F, Auinger M, Trenkwalder E, Irsigler K, Utermann G, Dieplinger H:
Is apolipoprotein(a) a susceptibility gene for type I diabetes mellitus and related to long-term survival?.
Diabetologia
42:1021-1027, 1999. PMID:
10491765
Journal Article
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Kronenberg F, Neyer U, Lhotta K, Trenkwalder E, Auinger M, Pribasnig A, Meisl T, König P, Dieplinger H:
The low molecular weight apo(a) phenotype is an independent predictor for coronary artery disease in hemodialysis patients: a prospective follow-up.
J. Am. Soc. Nephrol.
10:1027-1036, 1999. PMID:
10232689
Journal Article
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Kerschdorfer L, König P, Neyer U, Bösmüller C, Lhotta K, Auinger M, Hohenegger M, Riegler P, Margreiter R, Utermann G, Dieplinger H, Kronenberg F:
Lipoprotein(a) plasma concentrations after renal transplantation: a prospective evaluation after 4 years of follow-up.
Atherosclerosis
144:381-391, 1999. PMID:
10407499
Journal Article
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Schwelberger HG, Dieplinger H, Kohlwein SD:
Diamine oxidase and catalase are expressed in the same cells but are present in different subcellular compartments in porcine kidney.
Inflamm. Res.
48 Suppl 1:S81-2, 1999. PMID:
10350174
Journal Article
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Niemeier A, Willnow T, Dieplinger H, Jacobsen C, Meyer N, Hilpert J, Beisiegel U:
Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro.
Arterioscler. Thromb. Vasc. Biol.
19:552-561, 1999. PMID:
10073957
Journal Article
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Benlian P, Aalto-Setälä K, Dieplinger H, Hofker M, James R, Poledne R, Talmud P, Vilaro S:
European lipoprotein club: Report of the 21st annual conference, tutzing, September 28-October 1, 1998.
Atherosclerosis
144:449-458, 1999. PMID:
10407507
Journal Article
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Kronenberg F, Auinger M, Dieplinger H:
Genetic-epidemiological studies of apolipoprotein(a) polymorphism and its significance in nephrological diseases and type I diabetes mellitus.
Acta Med. Austriaca
26:142-147, 1999. PMID:
11512190
Review
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Dieplinger H:
Lipoprotein(a): the really bad cholesterol?.
Biochem. Soc. Trans.
27:439-447, 1999. PMID:
10917617
Review
1998 (2)
-
Kronenberg F, Trenkwalder E, Kronenberg MF, König P, Utermann G, Dieplinger H:
Influence of hematocrit on the measurement of lipoproteins demonstrated by the example of lipoprotein(a).
Kidney Int.
54:1385-1389, 1998. PMID:
9767560
Journal Article
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Lobentanz EM, Krasznai K, Gruber A, Brunner C, Müller HJ, Sattler J, Kraft HG, Utermann G, Dieplinger H:
Intracellular metabolism of human apolipoprotein(a) in stably transfected Hep G2 cells.
Biochemistry
37:5417-5425, 1998. PMID:
9548923
Journal Article
1997 (7)
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Trenkwalder E, Gruber A, König P, Dieplinger H, Kronenberg F:
Increased plasma concentrations of LDL-unbound apo(a) in patients with end-stage renal disease.
Kidney Int.
52:1685-1692, 1997. PMID:
9407518
Journal Article
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Kronenberg F, Trenkwalder E, Sturm W, Kathrein H, König P, Neyer U, Gröchenig E, Utermann G, Dieplinger H:
LDL-unbound apolipoprotein(a) and carotid atherosclerosis in hemodialysis patients.
Clin. Genet.
52:377-386, 1997. PMID:
9520130
Journal Article
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Kronenberg F, Trenkwalder E, Lingenhel A, Friedrich G, Lhotta K, Schober M, Moes N, König P, Utermann G, Dieplinger H:
Renovascular arteriovenous differences in Lp[a] plasma concentrations suggest removal of Lp[a] from the renal circulation.
J. Lipid Res.
38:1755-1763, 1997. PMID:
9323585
Journal Article
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Koch M, Kutkuhn B, Trenkwalder E, Bach D, Grabensee B, Dieplinger H, Kronenberg F:
Apolipoprotein B, fibrinogen, HDL cholesterol, and apolipoprotein(a) phenotypes predict coronary artery disease in hemodialysis patients.
J. Am. Soc. Nephrol.
8:1889-1898, 1997. PMID:
9402091
Journal Article
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Lobentanz EM, Dieplinger H:
Biogenesis of lipoprotein(a) in human and animal hepatocytes.
Electrophoresis
18:2677-2681, 1997. PMID:
9527497
Review
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Stalenhoef AF, Aalto-Setälä K, Armstrong VW, Benlian P, Dieplinger H, Humphries S, Steinmetz A:
The 19th annual meeting of the European Lipoprotein Club.
Arterioscler. Thromb. Vasc. Biol.
17:2316-2325, 1997. PMID:
9440953
Journal Article
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Reblin T, Niemeier A, Meyer N, Willnow TE, Kronenberg F, Dieplinger H, Greten H, Beisiegel U:
Cellular uptake of lipoprotein[a] by mouse embryonic fibroblasts via the LDL receptor and the LDL receptor-related protein.
J. Lipid Res.
38:2103-2110, 1997. PMID:
9374132
Journal Article
1996 (6)
-
Kronenberg F, Utermann G, Dieplinger H:
Lipoprotein(a) in renal disease.
Am. J. Kidney Dis.
27:Jan.25, 1996. PMID:
8546123
Review
-
Kronenberg F, Steinmetz A, Kostner GM, Dieplinger H:
Lipoprotein(a) in health and disease.
Crit. Rev. Clin. Lab. Sci.
33:495-543, 1996. PMID:
8989507
Review
-
Kronenberg F, Trenkwalder E, Dieplinger H, Utermann G:
Lipoprotein(a) in stored plasma samples and the ravages of time. Why epidemiological studies might fail.
Arterioscler. Thromb. Vasc. Biol.
16:1568-1572, 1996. PMID:
8977463
Journal Article
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Kronenberg F, Dieplinger H, König P, Utermann G:
Lipoprotein metabolism in renal replacement therapy: a review.
Isr. J. Med. Sci.
32:371-389, 1996. PMID:
8682643
Review
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Kostner KM, Maurer G, Huber K, Stefenelli T, Dieplinger H, Steyrer E, Kostner GM:
Urinary excretion of apo(a) fragments. Role in apo(a) catabolism.
Arterioscler. Thromb. Vasc. Biol.
16:905-911, 1996. PMID:
8696952
Journal Article
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Brunner C, Lobentanz EM, Pethö-Schramm A, Ernst A, Kang C, Dieplinger H, Müller HJ, Utermann G:
The number of identical kringle IV repeats in apolipoprotein(a) affects its processing and secretion by HepG2 cells.
J. Biol. Chem.
271:32403-32410, 1996. PMID:
8943305
Journal Article
1995 (9)
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Dieplinger H, Gruber G, Krasznai K, Reschauer S, Seidel C, Burns G, Müller HJ, Császár A, Vogel W, Robenek H:
Kringle 4 of human apolipoprotein[a] shares a linear antigenic site with human catalase.
J. Lipid Res.
36:813-822, 1995. PMID:
7542309
Journal Article
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Kronenberg F, König P, Neyer U, Auinger M, Pribasnig A, Meisl T, Pinter G, Dieplinger H:
Influence of various heparin preparations on lipoproteins in hemodialysis patients: a multicentre study.
Thromb. Haemost.
74:1025-1028, 1995. PMID:
8560405
Journal Article
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Kronenberg F, König P, Lhotta K, Steinmetz A, Dieplinger H:
Low molecular weight heparin does not necessarily reduce lipids and lipoproteins in hemodialysis patients.
Clin. Nephrol.
43:399-404, 1995. PMID:
7554525
Journal Article
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Kronenberg F, König P, Neyer U, Auinger M, Pribasnig A, Lang U, Reitinger J, Pinter G, Utermann G, Dieplinger H:
Multicenter study of lipoprotein(a) and apolipoprotein(a) phenotypes in patients with end-stage renal disease treated by hemodialysis or continuous ambulatory peritoneal dialysis.
J. Am. Soc. Nephrol.
6:110-120, 1995. PMID:
7579063
Journal Article
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Menzel HJ, Dieplinger H, Sandholzer C, Karádi I, Utermann G, Császár A:
Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants.
Hum. Mutat.
5:58-65, 1995. PMID:
7728150
Journal Article
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Kostner GM, Oettl K, Jauhiainen M, Ehnholm C, Esterbauer H, Dieplinger H:
Human plasma phospholipid transfer protein accelerates exchange/transfer of alpha-tocopherol between lipoproteins and cells.
Biochem. J.
305 ( Pt 2):659-667, 1995. PMID:
7832785
Journal Article
-
Holzfeind P, Merschak P, Dieplinger H, Redl B:
The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily.
Exp. Eye Res.
61:495-500, 1995. PMID:
8549691
Journal Article
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Burkhardt J, Huber LA, Dieplinger H, Blocker A, Griffiths G, Desjardins M:
Gaining insight into a complex organelle, the phagosome, using two-dimensional gel electrophoresis.
Electrophoresis
16:2249-2257, 1995. PMID:
8824784
Journal Article
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Kronenberg F, Königsrainer A, Lhotta K, Margreiter R, Dieplinger H, König P:
Conversion from cyclosporin to azathioprine after kidney transplantation.
Lancet
345:1503-4; author reply 1504-5, 1995. PMID:
7769912
Commentary
1994 (7)
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Kronenberg F, Lobentanz EM, König P, Utermann G, Dieplinger H:
Effect of sample storage on the measurement of lipoprotein[a], apolipoproteins B and A-IV, total and high density lipoprotein cholesterol and triglycerides.
J. Lipid Res.
35:1318-1328, 1994. PMID:
7964193
Journal Article
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Kronenberg F, Kathrein H, König P, Neyer U, Sturm W, Lhotta K, Gröchenig E, Utermann G, Dieplinger H:
Apolipoprotein(a) phenotypes predict the risk for carotid atherosclerosis in patients with end-stage renal disease.
Arterioscler. Thromb.
14:1405-1411, 1994. PMID:
8068600
Journal Article
-
Kronenberg F, König P, Lhotta K, Ofner D, Sandholzer C, Margreiter R, Dosch E, Utermann G, Dieplinger H:
Apolipoprotein(a) phenotype-associated decrease in lipoprotein(a) plasma concentrations after renal transplantation.
Arterioscler. Thromb.
14:1399-1404, 1994. PMID:
8068599
Journal Article
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Huby T, Doucet C, Dieplinger H, Chapman J, Thillet J:
Structural domains of apolipoprotein(a) and its interaction with apolipoprotein B-100 in the lipoprotein(a) particle.
Biochemistry
33:3335-3341, 1994. PMID:
8136370
Journal Article
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Steyrer E, Durovic S, Frank S, Giessauf W, Burger A, Dieplinger H, Zechner R, Kostner GM:
The role of lecithin: cholesterol acyltransferase for lipoprotein (a) assembly. Structural integrity of low density lipoproteins is a prerequisite for Lp(a) formation in human plasma.
J. Clin. Invest.
94:2330-2340, 1994. PMID:
7989589
Journal Article
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Frank S, Krasznai K, Durovic S, Lobentanz EM, Dieplinger H, Wagner E, Zatloukal K, Cotten M, Utermann G, Kostner GM:
High-level expression of various apolipoprotein(a) isoforms by "transferrinfection": the role of kringle IV sequences in the extracellular association with low-density lipoprotein.
Biochemistry
33:12329-12339, 1994. PMID:
7918455
Journal Article
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Desjardins M, Celis JE, van Meer G, Dieplinger H, Jahraus A, Griffiths G, Huber LA:
Molecular characterization of phagosomes.
J. Biol. Chem.
269:32194-32200, 1994. PMID:
7798218
Journal Article