Institute of Genetic Epidemiology

Our institute investigates the genetic, environmental, and biochemical determinants of health and disease. Our goal is to understand how these factors interact to influence physiological and pathophysiological processes. A major focus is on lipoprotein(a) to understand its genetic architecture, epidemiology, and role in cardiovascular risk.

We develop and apply cutting-edge molecular, statistical and computational methods to analyze large-scale genomic and biobank data, with the goal to advance precision medicine. Our research focuses on complex phenotypes that arise from the interplay of genes, environment, and metabolism. Key research areas include atherosclerosis, chronic kidney disease, diabetes mellitus, metabolic syndrome, cancer, lipoprotein metabolism, inflammation and mitochondrial genetics.

Our institute serves as a bridge between basic and clinical research. We work with genetic-epidemiological methods with association studies of candidate genes as well as hypothesis-free genome-wide association studies and also clinical-epidemiological methods. For functional studies, we use a variety of cell culture and animal models implementing state-of-the-art methods of protein chemistry and molecular biology. Finally, we develop computational solutions for problems related to medical genetic research and diagnosis.

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