Many students made their PhD, MD, master or diploma thesis during the last two decades. They have been or are still part of our team and we very much appreciate their contributions.

When considering writing a thesis at our institute, please have a look at the available theses. You can also suggest a topic that fits in our research fields.

Open Theses

Master Thesis
Application of polygenic riskscores and validation of clinical utility

Supervisor(s): This master thesis explores the application of polygenic risk scores (PRS) and validates their clinical utility. Polygenic risk scores aggregate information from multiple genetic variants to assess an individual's genetic susceptibility to certain traits or conditions. The study investigates the implementation of PRS in clinical contexts, assessing their effectiveness in predicting and stratifying risks. Additionally, the thesis delves into the validation of the clinical utility of PRS, considering factors such as accuracy, sensitivity, and specificity. Through comprehensive analysis and validation, this research contributes to the ongoing efforts to integrate genomic information into clinical decision-making processes.
PhD Thesis
Genome Informatics (PhD Student)

Supervisor(s): Polygenic risk scores (PRS) represent a novel approach in the field of genetics, to improve understanding of complex traits and diseases influenced by multiple genetic factors. Unlike single-gene analyses, PRS summarize information from numerous genetic variants scattered across an individual's genome to generate a comprehensive risk assessment. This thesis investigates innovative approaches to integrate advanced computational methods for more precise risk estimation and early detection of genetic predispositions.
Master Thesis
Measuring the glycoprotein afamin in a large cohort of chronic kidney disease (CKD) patients with subsequent statistical data analyses

Supervisor(s): The main aim of the project will be to be establish an ELISA (Enzyme-linked Immunosorbent Assay) to measure afamin in urine in >5000 CKD patients of the GCKD study. A further part of the project will be the possibility to do statistical data analyses. One subproject will be to identify metabolites and metabolite-pair ratios associated with serum and urine afamin concentrations and to then analyse the association of afamin with some of the known metabolites for CKD to illuminate the pathways linking afamin to CKD. Participation in further statistical analyses projects is possible.